Andy was first coached by his father, who originally placed him on the blueline, but moved him to forward when it became evident he'd be too small to make a career as a defenseman. He played in the Strathroy & District Minor Hockey Association and moved onto the Elgin-Middlesex Chiefs Triple A team.

 

Andy played Junior B hockey for the Strathroy Rockets. In 1994-1995, he was named the Rockets Most Valuable Player and had the best plus-minus as a forward. From the OHA he received Eastern Division MVP, League MVP, and the OHA Player of the Year. In 1995-1996, he again had the best plus-minus as a forward, was Rocket Player of the Year, MVP, and Playoff MVP. He also received the Eastern Division MVP, League MVP, and League Player of the Year that season. In the playoffs Andy scored the game winning goal in overtime of game six against the Aylmer Aces that gave the Rockets a huge upset win and their first playoff series win in 19 years.

 

After being spotted playing in the Western Ontario Junior Hockey League by Stan Moore and Chris Wells, Andy spent four years with a full scholarship at Colgate University alongside fellow Strathroy native Darryl Campbell, the older brother of the Buffalo Sabres' Brian Campbell. He led the Division I Red Raiders, culminating his career there with an ECAC scoring championship, being named the ECAC Player of the Year, being selected for the ECAC All-Star Team and was a finalist for the coveted Hobey Baker Award. He graduated with a degree in International Relations.

 

He went undrafted and was signed as a free-agent by Anaheim in 2000. On December 3, 2000 he scored his first NHL goal against Jamie Storr of the Los Angeles Kings.

 

Concussion problems plagued his first three seasons with the Ducks, and he was forced to sit and watch when the team made a run at the Stanley Cup in 2003.

 

On January 19, 2007 McDonald was selected to play in his first NHL All-Star game, replacing Detroit Red Wings forward Henrik Zetterberg who was injured. During the skills competition, McDonald won the fastest skater challenge, finishing with a time of 14.03 seconds (Mike Gartner holds the record of 13.386).

 

On June 4, 2007, during game four of the Stanley Cup finals against the Ottawa Senators, McDonald contributed on all 3 of the Ducks goals, scoring two goals and an assist, en route to a 3-2 victory. McDonald was named the first star of the game on the official scoresheet. He finished with five goals in the series as the Ducks won the Stanley Cup in five games.

 

McDonald and his wife Gina celebrated the birth of their first child, Jake Gene McDonald, on October 8, 2007 at 12:50 p.m. Jake was 7 lbs., 5 oz.

 

On December 14, 2007, in order for the Anaheim Ducks to free up salary cap space for Scott Neidermayer, McDonald was traded to the St. Louis Blues for Doug Weight.